منابع مشابه
Junction-forming aquaporins.
Aquaporins (AQPs) are a family of ubiquitous membrane channels that conduct water and solutes across membranes. This review focuses on AQP0 and AQP4, which in addition to forming water channels also appear to play a role in cell adhesion. We discuss the recently determined structures of the membrane junctions mediated by these two AQPs, the mechanisms that regulate junction formation, and evide...
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and take over the discipline. If we want to make sure that the biology of the future preserves our hard-won biological perspectives, knowledge and insights, we need to be able to do the analyses and deal with all these data ourselves. For young scientists embarking on a PhD, make sure your PhD topic is something you love, and that your question is one whose answer you care deeply about. Don’t s...
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DNA methylation is an epigenetic mechanism for transcriptional regulation. The methylation process controls cellular differentiation and is defective in many diseases including cancer. Therefore, the development of a simple method for analysing cytosine methylation in a target gene is required. Here we report a conceptually new method for sequence-selective chemical modification of a single cyt...
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The mechanism of epithelial fluid transport remains unsolved, which is partly due to inherent experimental difficulties. However, a preparation with which our laboratory works, the corneal endothelium, is a simple leaky secretory epithelium in which we have made some experimental and theoretical headway. As we have reported, transendothelial fluid movements can be generated by electrical curren...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2008
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2007.11.003